Big Prefix Crossword Clue — 4 Letters

One confident answer with explanation of the wordplay

MEGA
Best match
M
E
G
A

MEGA is a prefix meaning "big" or "large" (e.g., megaphone, megalopolis). It's a very common crossword answer for clues about "big" prefixes, fitting perfectly at 4 letters.

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Other possible answers
MACRMACRO- is a prefix meaning large/big, but MACR alone is less standard as a standalone answer
GRANGRAND/GRANDE relates to big, but less commonly used as a 'big prefix' in crosswords
GIGAGIGA is a prefix meaning very large (billion), related to 'big' but less directly than MEGA

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